Spore Lecture from GDC
Check out this video of Will Wright's lecture about Spore at GDC. This game looks amazing.
You build a society from the cellular level, constantly evolving you species. It starts almost like Pac Man where you eat what you need to survive and ultimately becomes a cross between an RTS and Sim City.
The video is about half an hour long and worth watching. This sort of reminds me of when Lisa Simpson built a whole society out of a tooth and a static shock for a science project.